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Jellyfish Inspires Cancer Detector
Jellyfish tentacles have inspired a way to detect cancer, microbes and viruses, researchers say.
Devices resulting from this research could help quickly and sensitively detect life-threatening diseases and capture dangerous cells for analysis so that doctors can devise the best therapies to fight them, investigators added.
Jellyfish and relatives of theirs such as sea anemones capture prey flowing past them with long tentacles coated with multiple sticky patches. These sea animals guided scientists to develop a novel microchip covered with a network of long DNA strands that could grab onto proteins as they floated by.
"Nature has overcome the most challenging barriers … Evolution really is the best problem-solver, and there is so much we can learn from nature," bioengineer Jeffrey Karp, co-director of the Center for Regenerative Therapeutics at Brigham and Women's Hospital in Boston, told TechNewsDaily.
DNA is the molecule that holds the blueprints of life. Sequences of DNA known as aptamers also show a remarkable ability to bind onto very specific targets.
To test their device, Karp and his colleagues generated long DNA strands with aptamers that would bind onto a protein found abundantly on the surfaces of human cancer cells. The strands are up to hundreds of microns long — in comparison, the average human hair is about 100 microns wide. The length of these strands gives them more area to snag onto target proteins and their associated cells than other methods that employ antibodies or shorter DNA strands.
In addition, the strands are anchored onto a microchannel with a herringbone pattern on its floor. The patterned ridges cause blood to swirl as it flows through the channel, improving the chances that cells will come into contact with the DNA tentacles.
In experiments, blood samples containing leukemia cells were flowed past the device. These long DNA tentacles efficiently captured up to about 80 percent of these cells, about six times more than methods relying on antibodies or shorter DNA strands.
"The chip we have developed is highly sensitive," said researcher Weian Zhao, formerly at Karp's lab, now at the University of California, Irvine. "From just a tiny amount of blood, the chip can detect and capture the small population of cancer cells responsible for cancer relapse."In addition to hunting for blood-based cancers, the device might also find cancer cells that have broken away from tumors and are traveling through the bloodstream. Roaming cancers known as metastases are the leading cause of deaths from cancer, but these wandering cells are very rare in the bloodstream, with just a few to several thousand per milliliter of a patient's blood.
"Our device has the potential to catch these cells in the act with its 'tentacles' before they may seed a new tumor in a distant organ," Karp said.
In addition, the device could handle rates of flow 10 times faster than comparable methods. The researchers say they could boost this speed 100-fold, suggesting the system might be fast enough for practical use in the clinic.
"If you had a rapid test that could tell you whether there are more or less of these cells over time, especially those cells that can specifically seed a metastasis, that would help to monitor the progression of therapy and progression of the disease," Karp said.
Moreover, the device was able to later release entrapped cells so researchers could grow them in the laboratory. This could help enable personalized therapies — once cells are isolated from a patient, doctors could test a variety of drugs on them to see which might be most effective.
"One of the greatest challenges in the treatment of cancer patients is to know which drug to prescribe," Karp said. "By isolating circulating tumor cells before and after the first round of chemotherapy is given, we can determine the biology behind why certain cells are resistant to chemotherapy. We can also use the isolated cells to screen drugs for personalized treatments that could boost effectiveness and hopefully prevent cancer relapse."
The researchers can readily tailor the DNA tentacles to bind onto other targets, such as microbes and viruses. For instance, by targeting fetal cells that are very rare in a pregnant woman's bloodstream, the device could help doctors perform prenatal diagnostic tests for a range of diseases, an approach far less invasive than amniocentesis, which involves sticking a needle into the tissue surrounding the fetus.
"We are now gearing up to test our approach on patient samples," Karp said. "The major obstacle ahead of us is resources. The more we have, the more aggressively we can pursue this approach and advance it to the clinic."
Zhao, Karp and their colleague Rohit Karnik detailed their findings online Nov. 12 in the journal Proceedings of the National Academy of Sciences.
Source: http://www.technewsdaily.com/15583-jellyfish-inspires-cancer-detector.html
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Founded by Russian entrepreneur Dmitry Itskov in February 2011 with the participation of leading Russian specialists in the field of neural interfaces, robotics, artificial organs and systems.
The main goals of the 2045 Initiative: the creation and realization of a new strategy for the development of humanity which meets global civilization challenges; the creation of optimale conditions promoting the spiritual enlightenment of humanity; and the realization of a new futuristic reality based on 5 principles: high spirituality, high culture, high ethics, high science and high technologies.
The main science mega-project of the 2045 Initiative aims to create technologies enabling the transfer of a individual’s personality to a more advanced non-biological carrier, and extending life, including to the point of immortality. We devote particular attention to enabling the fullest possible dialogue between the world’s major spiritual traditions, science and society.
A large-scale transformation of humanity, comparable to some of the major spiritual and sci-tech revolutions in history, will require a new strategy. We believe this to be necessary to overcome existing crises, which threaten our planetary habitat and the continued existence of humanity as a species. With the 2045 Initiative, we hope to realize a new strategy for humanity's development, and in so doing, create a more productive, fulfilling, and satisfying future.
The "2045" team is working towards creating an international research center where leading scientists will be engaged in research and development in the fields of anthropomorphic robotics, living systems modeling and brain and consciousness modeling with the goal of transferring one’s individual consciousness to an artificial carrier and achieving cybernetic immortality.
An annual congress "The Global Future 2045" is organized by the Initiative to give platform for discussing mankind's evolutionary strategy based on technologies of cybernetic immortality as well as the possible impact of such technologies on global society, politics and economies of the future.
Future prospects of "2045" Initiative for society
2015-2020
The emergence and widespread use of affordable android "avatars" controlled by a "brain-computer" interface. Coupled with related technologies “avatars’ will give people a number of new features: ability to work in dangerous environments, perform rescue operations, travel in extreme situations etc.
Avatar components will be used in medicine for the rehabilitation of fully or partially disabled patients giving them prosthetic limbs or recover lost senses.
2020-2025
Creation of an autonomous life-support system for the human brain linked to a robot, ‘avatar’, will save people whose body is completely worn out or irreversibly damaged. Any patient with an intact brain will be able to return to a fully functioning bodily life. Such technologies will greatly enlarge the possibility of hybrid bio-electronic devices, thus creating a new IT revolution and will make all kinds of superimpositions of electronic and biological systems possible.
2030-2035
Creation of a computer model of the brain and human consciousness with the subsequent development of means to transfer individual consciousness onto an artificial carrier. This development will profoundly change the world, it will not only give everyone the possibility of cybernetic immortality but will also create a friendly artificial intelligence, expand human capabilities and provide opportunities for ordinary people to restore or modify their own brain multiple times. The final result at this stage can be a real revolution in the understanding of human nature that will completely change the human and technical prospects for humanity.
2045
This is the time when substance-independent minds will receive new bodies with capacities far exceeding those of ordinary humans. A new era for humanity will arrive! Changes will occur in all spheres of human activity – energy generation, transportation, politics, medicine, psychology, sciences, and so on.
Today it is hard to imagine a future when bodies consisting of nanorobots will become affordable and capable of taking any form. It is also hard to imagine body holograms featuring controlled matter. One thing is clear however: humanity, for the first time in its history, will make a fully managed evolutionary transition and eventually become a new species. Moreover, prerequisites for a large-scale expansion into outer space will be created as well.
Key elements of the project in the future
• International social movement
• social network immortal.me
• charitable foundation "Global Future 2045" (Foundation 2045)
• scientific research centre "Immortality"
• business incubator
• University of "Immortality"
• annual award for contribution to the realization of the project of "Immortality”.
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