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17.05.2013

This Bacterium Can Do Division, Compute Logarithms And Take Square Roots

A group of engineers from MIT have created analog calculators out of living cells, according to a paper published online in Nature yesterday. By tweaking the genes of bacterial cells, the researchers were able to create circuits that can perform calculations--including division, multiplication, logarithms and square roots--in a much more efficient way than many existing biocomputers.

Using analog circuits, which harness a cell's natural biochemical functions, allows for more nuanced computations than imposing digital logic. While digital circuits classify all values as zeros and ones, analog circuits can handle a continuous range of inputs, allowing for values in between. In addition to computing whether or not a molecule like glucose is present, these circuits can tell its concentration, for instance.

“Analog computation is very efficient,” senior author Rahul Sarpeshkar said in a press statement. “To create digital circuits at a comparable level of precision would take many more genetic parts.”

A synthetic circuit that calculates square roots, for example, requires more than 100 parts, while the MIT team's analog circuit only uses two parts.

To create a circuit that could multiply, researchers combined two circuits that both turn on the genes for green fluorescent protein, or GFP. One used a sugar called arabinose, and the other used a signaling molecule called AHL. The combined input from both are then calculated using the total amount of GFP.

The cell divides using the same enzyme mechanism that helps it calculate the ratios of different molecules. The researchers modified the circuits to expand their range and compute inputs up to 10,000.

The researcher's future goal is to replicate their success with bacterial cells in larger cells, including mammalian cells. Karpeshkar aims to create new circuits that can improve gene expression, molecular sensing and computation, according to MIT. “We have just scratched the surface of what sophisticated analog feedback circuits can do in living cells,” he said.

[MIT]

Source: http://www.popsci.com/science/article/2013-05/cell-can-do-division-compute-logarithms-and-take-square-roots




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Founded by Russian entrepreneur Dmitry Itskov in February 2011 with the participation of leading Russian specialists in the field of neural interfaces, robotics, artificial organs and systems.

The main goals of the 2045 Initiative: the creation and realization of a new strategy for the development of humanity which meets global civilization challenges; the creation of optimale conditions promoting the spiritual enlightenment of humanity; and the realization of a new futuristic reality based on 5 principles: high spirituality, high culture, high ethics, high science and high technologies. 

The main science mega-project of the 2045 Initiative aims to create technologies enabling the transfer of a individual’s personality to a more advanced non-biological carrier, and extending life, including to the point of immortality. We devote particular attention to enabling the fullest possible dialogue between the world’s major spiritual traditions, science and society.

A large-scale transformation of humanity, comparable to some of the major spiritual and sci-tech revolutions in history, will require a new strategy. We believe this to be necessary to overcome existing crises, which threaten our planetary habitat and the continued existence of humanity as a species. With the 2045 Initiative, we hope to realize a new strategy for humanity's development, and in so doing, create a more productive, fulfilling, and satisfying future.

The "2045" team is working towards creating an international research center where leading scientists will be engaged in research and development in the fields of anthropomorphic robotics, living systems modeling and brain and consciousness modeling with the goal of transferring one’s individual consciousness to an artificial carrier and achieving cybernetic immortality.

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2015-2020

The emergence and widespread use of affordable android "avatars" controlled by a "brain-computer" interface. Coupled with related technologies “avatars’ will give people a number of new features: ability to work in dangerous environments, perform rescue operations, travel in extreme situations etc.
Avatar components will be used in medicine for the rehabilitation of fully or partially disabled patients giving them prosthetic limbs or recover lost senses.

2020-2025

Creation of an autonomous life-support system for the human brain linked to a robot, ‘avatar’, will save people whose body is completely worn out or irreversibly damaged. Any patient with an intact brain will be able to return to a fully functioning  bodily life. Such technologies will  greatly enlarge  the possibility of hybrid bio-electronic devices, thus creating a new IT revolution and will make  all  kinds of superimpositions of electronic and biological systems possible.

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This is the time when substance-independent minds will receive new bodies with capacities far exceeding those of ordinary humans. A new era for humanity will arrive!  Changes will occur in all spheres of human activity – energy generation, transportation, politics, medicine, psychology, sciences, and so on.

Today it is hard to imagine a future when bodies consisting of nanorobots  will become affordable  and capable of taking any form. It is also hard to imagine body holograms featuring controlled matter. One thing is clear however:  humanity, for the first time in its history, will make a fully managed evolutionary transition and eventually become a new species. Moreover,  prerequisites for a large-scale  expansion into outer space will be created as well.

 

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