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Algorithm developed for anti-aging remedy search
PT scientists have provided an algorithm which can help in the search for aging-suppressing drugs. The researchers, whose work is published in Frontiers in Genetics magazine, have compared gene expression in young and elderly patients' cells.
The scientists -- Alexander Zhavoronkov, Anton Buzdin, Andrey Garazha, Nickolay Borisov and Alexey Moskalev- have based the new research on their previously-developed methods in the study of cancer cells. Each cell uses particular schemes of molecular interaction, which physiologists call intercellular signaling pathways.
A signaling pathway is a chain of sequential events of interaction between certain molecules which make the cell respond to stimulation. For example, hormone molecules first interact with the cell's membrane receptors, then the receptors engage with the molecules inside the cell, and those, in turn, deliver the signal into the cell's nucleus. As a result, inside the nucleus there occur changes in the way certain proteins engage with DNA and in the expression of genes. This leads to changes in the synthesis of RNA molecules, which are responsible for protein-producing processes.
Events in a cell's life-cycle can be roughly of two types: normal (such as hormone-induced response or performance of certain functions related to body growth) and abnormal, or pathological (i.e., malignant degeneration). Both these types of events are accompanied by changes in signaling pathway activity. What is more important, the same chain of reactions can be traced in totally different processes, i.e., there is no such thing as a "malignant cell forming protein," or a "long-term memory protein."
The team of experts from MIPT and other Russian and British organizations (the full list of names can be found in the article) suggested comparing peculiarities of signaling pathways activation in young and aging cells. This information is then expanded with the available data on the impact of various substances on signaling pathways.
Thus, the new algorithm helps to predict the type of change in the profile of intracellular molecular interaction which will occur in response to this or that drug.
In their article the scientists point out that their algorithm can be used in rapid and inexpensive search for drugs which can minimize the difference between the cells of young and elderly patients. This means that it will be possible to speed up the search for longevity drugs and decrease its cost. What is more, this will be achieved not by simply fighting some particular diseases, but by a complex influence on the mechanisms of aging.
Story Source:
The above story is based on materials provided by Moscow Institute of Physics and Technology. Note: Materials may be edited for content and length.
Journal Reference:
- Alex Zhavoronkov, Anton A. Buzdin, Andrey V. Garazha, Nikolay M. Borisov, Alexey A. Moskalev. Signaling pathway cloud regulation for in silico screening and ranking of the potential geroprotective drugs. Frontiers in Genetics, 2014; 5 DOI: 10.3389/fgene.2014.00049
Source: http://www.sciencedaily.com/releases/2014/05/140515113336.htm
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Founded by Russian entrepreneur Dmitry Itskov in February 2011 with the participation of leading Russian specialists in the field of neural interfaces, robotics, artificial organs and systems.
The main goals of the 2045 Initiative: the creation and realization of a new strategy for the development of humanity which meets global civilization challenges; the creation of optimale conditions promoting the spiritual enlightenment of humanity; and the realization of a new futuristic reality based on 5 principles: high spirituality, high culture, high ethics, high science and high technologies.
The main science mega-project of the 2045 Initiative aims to create technologies enabling the transfer of a individual’s personality to a more advanced non-biological carrier, and extending life, including to the point of immortality. We devote particular attention to enabling the fullest possible dialogue between the world’s major spiritual traditions, science and society.
A large-scale transformation of humanity, comparable to some of the major spiritual and sci-tech revolutions in history, will require a new strategy. We believe this to be necessary to overcome existing crises, which threaten our planetary habitat and the continued existence of humanity as a species. With the 2045 Initiative, we hope to realize a new strategy for humanity's development, and in so doing, create a more productive, fulfilling, and satisfying future.
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Future prospects of "2045" Initiative for society
2015-2020
The emergence and widespread use of affordable android "avatars" controlled by a "brain-computer" interface. Coupled with related technologies “avatars’ will give people a number of new features: ability to work in dangerous environments, perform rescue operations, travel in extreme situations etc.
Avatar components will be used in medicine for the rehabilitation of fully or partially disabled patients giving them prosthetic limbs or recover lost senses.
2020-2025
Creation of an autonomous life-support system for the human brain linked to a robot, ‘avatar’, will save people whose body is completely worn out or irreversibly damaged. Any patient with an intact brain will be able to return to a fully functioning bodily life. Such technologies will greatly enlarge the possibility of hybrid bio-electronic devices, thus creating a new IT revolution and will make all kinds of superimpositions of electronic and biological systems possible.
2030-2035
Creation of a computer model of the brain and human consciousness with the subsequent development of means to transfer individual consciousness onto an artificial carrier. This development will profoundly change the world, it will not only give everyone the possibility of cybernetic immortality but will also create a friendly artificial intelligence, expand human capabilities and provide opportunities for ordinary people to restore or modify their own brain multiple times. The final result at this stage can be a real revolution in the understanding of human nature that will completely change the human and technical prospects for humanity.
2045
This is the time when substance-independent minds will receive new bodies with capacities far exceeding those of ordinary humans. A new era for humanity will arrive! Changes will occur in all spheres of human activity – energy generation, transportation, politics, medicine, psychology, sciences, and so on.
Today it is hard to imagine a future when bodies consisting of nanorobots will become affordable and capable of taking any form. It is also hard to imagine body holograms featuring controlled matter. One thing is clear however: humanity, for the first time in its history, will make a fully managed evolutionary transition and eventually become a new species. Moreover, prerequisites for a large-scale expansion into outer space will be created as well.
Key elements of the project in the future
• International social movement
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• University of "Immortality"
• annual award for contribution to the realization of the project of "Immortality”.
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