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Biologically powered chip created
Columbia Engineering researchers have, for the first time, harnessed the molecular machinery of living systems to power an integrated circuit from adenosine triphosphate (ATP), the energy currency of life. They achieved this by integrating a conventional solid-state complementary metal-oxide-semiconductor (CMOS) integrated circuit with an artificial lipid bilayer membrane containing ATP-powered ion pumps, opening the door to creating entirely new artificial systems that contain both biological and solid-state components. The study, led by Ken Shepard, Lau Family Professor of Electrical Engineering and professor of biomedical engineering at Columbia Engineering, is published online Dec. 7 inNature Communications.
"In combining a biological electronic device with CMOS, we will be able to create new systems not possible with either technology alone," says Shepard. "We are excited at the prospect of expanding the palette of active devices that will have new functions, such as harvesting energy from ATP, as was done here, or recognizing specific molecules, giving chips the potential to taste and smell. This was quite a unique new direction for us and it has great potential to give solid-state systems new capabilities with biological components."
Shepard, whose lab is a leader in the development of engineered solid-state systems interfaced to biological systems, notes that despite its overwhelming success, CMOS solid-state electronics is incapable of replicating certain functions natural to living systems, such as the senses of taste and smell and the use of biochemical energy sources. Living systems achieve this functionality with their own version of electronics based on lipid membranes and ion channels and pumps, which act as a kind of 'biological transistor.' They use charge in the form of ions to carry energy and information -- ion channels control the flow of ions across cell membranes. Solid-state systems, such as those in computers and communication devices, use electrons; their electronic signaling and power are controlled by field-effect transistors.
In living systems, energy is stored in potentials across lipid membranes, in this case created through the action of ion pumps. ATP is used to transport energy from where it is generated to where it is consumed in the cell. To build a prototype of their hybrid system, Shepard's team, led by PhD student Jared Roseman, packaged a CMOS integrated circuit (IC) with an ATP-harvesting 'biocell.' In the presence of ATP, the system pumped ions across the membrane, producing an electrical potential harvested by the IC.
"We made a macroscale version of this system, at the scale of several millimeters, to see if it worked," Shepard notes. "Our results provide new insight into a generalized circuit model, enabling us to determine the conditions to maximize the efficiency of harnessing chemical energy through the action of these ion pumps. We will now be looking at how to scale the system down."
While other groups have harvested energy from living systems, Shepard and his team are exploring how to do this at the molecular level, isolating just the desired function and interfacing this with electronics. "We don't need the whole cell," he explains. "We just grab the component of the cell that's doing what we want. For this project, we isolated the ATPases because they were the proteins that allowed us to extract energy from ATP."
The ability to build a system that combines the power of solid-state electronics with the capabilities of biological components has great promise. "You need a bomb-sniffing dog now, but if you can take just the part of the dog that is useful -- the molecules that are doing the sensing -- we wouldn't need the whole animal," says Shepard.
"With appropriate scaling, this technology could provide a power source for implanted systems in ATP-rich environments such as inside living cells," added Roseman.
Story Source:
The above post is reprinted from materials provided by Columbia University School of Engineering and Applied Science. Note: Materials may be edited for content and length.
Journal Reference:
- Jared M. Roseman, Jianxun Lin, Siddharth Ramakrishnan, Jacob K. Rosenstein, Kenneth L. Shepard. Hybrid integrated biological–solid-state system powered with adenosine triphosphate. Nature Communications, 2015; 6: 10070 DOI: 10.1038/NCOMMS10070
Source: http://www.sciencedaily.com/releases/2015/12/151207081815.htm
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Founded by Russian entrepreneur Dmitry Itskov in February 2011 with the participation of leading Russian specialists in the field of neural interfaces, robotics, artificial organs and systems.
The main goals of the 2045 Initiative: the creation and realization of a new strategy for the development of humanity which meets global civilization challenges; the creation of optimale conditions promoting the spiritual enlightenment of humanity; and the realization of a new futuristic reality based on 5 principles: high spirituality, high culture, high ethics, high science and high technologies.
The main science mega-project of the 2045 Initiative aims to create technologies enabling the transfer of a individual’s personality to a more advanced non-biological carrier, and extending life, including to the point of immortality. We devote particular attention to enabling the fullest possible dialogue between the world’s major spiritual traditions, science and society.
A large-scale transformation of humanity, comparable to some of the major spiritual and sci-tech revolutions in history, will require a new strategy. We believe this to be necessary to overcome existing crises, which threaten our planetary habitat and the continued existence of humanity as a species. With the 2045 Initiative, we hope to realize a new strategy for humanity's development, and in so doing, create a more productive, fulfilling, and satisfying future.
The "2045" team is working towards creating an international research center where leading scientists will be engaged in research and development in the fields of anthropomorphic robotics, living systems modeling and brain and consciousness modeling with the goal of transferring one’s individual consciousness to an artificial carrier and achieving cybernetic immortality.
An annual congress "The Global Future 2045" is organized by the Initiative to give platform for discussing mankind's evolutionary strategy based on technologies of cybernetic immortality as well as the possible impact of such technologies on global society, politics and economies of the future.
Future prospects of "2045" Initiative for society
2015-2020
The emergence and widespread use of affordable android "avatars" controlled by a "brain-computer" interface. Coupled with related technologies “avatars’ will give people a number of new features: ability to work in dangerous environments, perform rescue operations, travel in extreme situations etc.
Avatar components will be used in medicine for the rehabilitation of fully or partially disabled patients giving them prosthetic limbs or recover lost senses.
2020-2025
Creation of an autonomous life-support system for the human brain linked to a robot, ‘avatar’, will save people whose body is completely worn out or irreversibly damaged. Any patient with an intact brain will be able to return to a fully functioning bodily life. Such technologies will greatly enlarge the possibility of hybrid bio-electronic devices, thus creating a new IT revolution and will make all kinds of superimpositions of electronic and biological systems possible.
2030-2035
Creation of a computer model of the brain and human consciousness with the subsequent development of means to transfer individual consciousness onto an artificial carrier. This development will profoundly change the world, it will not only give everyone the possibility of cybernetic immortality but will also create a friendly artificial intelligence, expand human capabilities and provide opportunities for ordinary people to restore or modify their own brain multiple times. The final result at this stage can be a real revolution in the understanding of human nature that will completely change the human and technical prospects for humanity.
2045
This is the time when substance-independent minds will receive new bodies with capacities far exceeding those of ordinary humans. A new era for humanity will arrive! Changes will occur in all spheres of human activity – energy generation, transportation, politics, medicine, psychology, sciences, and so on.
Today it is hard to imagine a future when bodies consisting of nanorobots will become affordable and capable of taking any form. It is also hard to imagine body holograms featuring controlled matter. One thing is clear however: humanity, for the first time in its history, will make a fully managed evolutionary transition and eventually become a new species. Moreover, prerequisites for a large-scale expansion into outer space will be created as well.
Key elements of the project in the future
• International social movement
• social network immortal.me
• charitable foundation "Global Future 2045" (Foundation 2045)
• scientific research centre "Immortality"
• business incubator
• University of "Immortality"
• annual award for contribution to the realization of the project of "Immortality”.
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